Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.600 Biomarker disease RGD Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. 28598964 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.250 Biomarker disease RGD MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc. 28598964 2017
Entrez Id: 1812
Gene Symbol: DRD1
DRD1 		0.230 Biomarker disease RGD Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. 28598964 2017
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1 		0.230 Biomarker disease RGD A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. 24725195 2015
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.210 Biomarker disease RGD Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. 28598964 2017
Entrez Id: 355
Gene Symbol: FAS
FAS 		0.200 Biomarker disease RGD This study was mainly designed to quantitate Fas proteins in rat brain during heroin addiction and opiate withdrawal. 14530904 2003
Entrez Id: 18
Gene Symbol: ABAT
ABAT 		0.200 Biomarker disease RGD Increased mesolimbic GABA concentration blocks heroin self-administration in the rat. 10900239 2000
Entrez Id: 5179
Gene Symbol: PENK
PENK 		0.200 Biomarker disease RGD Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. 22683090 2012
Entrez Id: 1815
Gene Symbol: DRD4
DRD4 		0.060 GeneticVariation disease LHGDN The results of our study suggest that DRD4 VNTR polymorphism contributes to cue-elicited craving in heroin dependence, indicating DRD4 VNTR represents one of potential genetic risk factors for cue-induced craving. 16703401 2006
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A 		0.020 Biomarker disease LHGDN Our findings support a contribution of the 5-HT(2A) gene to susceptibility to heroin dependence, as well as a possible synergistic effect of 5-HT(2A) and 5-HTT genes on susceptibility to heroin dependence. 18182772 2008
Entrez Id: 8863
Gene Symbol: PER3
PER3 		0.010 GeneticVariation disease LHGDN The purpose of this study is to determine whether the 54-nucleotide repeat polymorphism of hPer3, one of the circadian clock genes, associates with heroin dependence. 17451453 2008
Entrez Id: 4158
Gene Symbol: MC2R
MC2R 		0.010 GeneticVariation disease LHGDN Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction. 18359160 2008
Entrez Id: 56899
Gene Symbol: ANKS1B
ANKS1B 		0.110 GeneticVariation disease GWASCAT Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. 31462767 2019
Entrez Id: 146849
Gene Symbol: CCDC42
CCDC42 		0.110 GeneticVariation disease GWASCAT Genome-Wide Association of Heroin Dependence in Han Chinese. 27936112 2016
Entrez Id: 84871
Gene Symbol: AGBL4
AGBL4 		0.100 GeneticVariation disease GWASCAT Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. 31462767 2019
Entrez Id: 1496
Gene Symbol: CTNNA2
CTNNA2 		0.100 GeneticVariation disease GWASCAT Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. 31462767 2019
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.600 Biomarker disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 Biomarker disease CTD_human Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. 20201854 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.380 Biomarker disease CTD_human Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. 17715210 2007
Entrez Id: 4803
Gene Symbol: NGF
NGF 		0.320 Biomarker disease CTD_human Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. 17715210 2007
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Adrenocorticotropic hormone and cortisol plasma levels directly correlate with childhood neglect and depression measures in addicted patients. 18201294 2008
Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2 		0.300 Biomarker disease CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005
Entrez Id: 56729
Gene Symbol: RETN
RETN 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005